Celecoxib is used to treat arthritis, pain, menstrual cramps, and colonic polyps. Celebrex is used to decrease growths found in the intestines of persons with a family history of this condition. Individuals who have developed allergic reactions from aspirin or other NSAIDs may experience an allergic reaction to Celecoxib and should not take Celecoxib. Fluconazole increases the concentration of Celecoxib in the body by inhibiting the breakdown of Celecoxib in the body by inhibiting the breakdown of Celecoxib in the liver. Celecoxib is used to decrease growths found in the intestines of persons with a family history of this condition.